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This is because its a naturally occurring peptide produced in the body

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49 Furthermore, the evidence includes NSAIDs gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation against deterioration after intestine resection

All of them examined young men aged 25 [21] to 34 [20]

Assessment and medication application The analgesia test was performed on the mice receiving morphine prior to the tested agents (i), and on the mice receiving no morphine prior to tested agents (ii), using the hot plate (Ugo Basille, Italy)