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A study that looked at 0.5-1mg/kg/day leucovorin in patients with cerebral folate deficiency (and related neurological symptoms) found that 90% of those supplemented achieved normal 5-methyltetrahydrofolate cerebral spinal fluid concentrations
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Consequently, the development of robust CRISPR-based systems for operating on large DNA fragments and their applications will be a significant aspect of CRISPRs role in the biosynthesis of bioactive compounds from plants in the future

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78 The effect of exogenous GSH on antibiotic susceptibility is summarized in Table 1
