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10.1038/s41598-018-33385-z Summary Keywords nitazoxanide, methotrexate, hepatotoxicity, endoplasmic reticulum stress, rat Citation Mahmoud NM, Elshazly SM, El-shaarawy F, Zaitone SA, Aldahish AA, Ahmed GA, Fawzy MS, Aloyouni SY, Abed SY, Saeedi T and El-Sayed SS (2024) Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

Superoxide dismutase (SOD) is the first line of antioxidant system and catalyzes the dismutation of O 2 into H 2 O 2 , which is then decomposed by CAT and GPX

Knockdown of NCOA4 inhibits ferroptosis in various tumor cell lines, which could be correlated with reduced intracellular free iron pools ( SystemX c /glutathione axis SystemX c is a heterodimer cell surface amino acid transporter extensively located in the cell membrane, which is a vital component of the cellular antioxidant system (Sato et al., 1999)

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