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These data, combined with the dot blot results, support the hypothesis that 4-HNE causes protein damage to which L

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Future work will also mechanistically address how the kinetics of PDHC and OGDC inhibition and recovery under specific conditions are affected by the quantitative distribution of these lipoic adducts, and to what extent the reduction of RNS-mediated modifications and the general turnover of PDHC and OGDC contribute to their recovery

The New England Journal of Medicine , 370 , 20712082