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Enhanced glycolysis-derived lactate promotes microglial activation in Parkinsons disease via histone lactylation

A growing literature highlights REDOX imbalance (a state in which demand for antioxidants surpasses their bioavailability) as a common pathophysiology for a diverse array of brain conditions (e.g., trichotillomania, schizophrenia, autism, Parkinsons disease)

Atomic coordinates referenced in the main text can be found through 1B33, 3MWN

doi: 10.1016/S0002-9440(10)62478-9

Because B vitamins are not stored in the body long-term, supplementation may help maintain optimal levels and support daily wellness

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