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The pathogenesis of DPN is influenced by metabolic, vascular, and genetic factors, with oxidative stress playing a significant role in nerve injury [153,154]

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In addition, MAMs constitute an important platform for phospholipid metabolism and are enriched in phosphatidylserine synthase (PSS) and oxysterol-binding protein-related proteins (ORP5/8)

That distinction is not academic

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Because some FIDE SNPs with unaligned enrollment may need to transition to a HIDE SNP status, such plans run the risk of losing the FIDE SNP frailty adjustment