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2010;299:E61523

For cell treatment by APAP precursors, HepaRG cells and primary human hepatocytes were first incubated with 50 g/ml of APAP or APAP-cys in the maintenance medium described above, during 0.5 h, 2 h, 6 h, 24 h, or 48 h, to optimize the incubation time required to detect APAP metabolites

Interestingly, within the same study on lung cancer risk, the effect of the Pro/Pro genotype in conferring risk or protection differed according to smoking status, but only in those diagnosed with cancer at an older age (399)

Macrophages are immune cells with antigen-presenting and phagocytic properties and have critical functions in the initiation and perpetuation of RA synovitis