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Effects on mitochondrial function in tissues like skeletal muscle have been observed within hours, but structural and functional benefits in conditions like AMD, Barth, and kidney disease typically take months of continuous dosing

Chen et al., 2003) and overexpression of Nrf1 and Nrf2 has been shown to induce the human GCLC promoter activity (Myhrstad et al., 2001

M.IordacheF.PignatelliF.et al

As mentioned before, other microbial-derived products with a role in atherosclerosis are Trimethylamine-N-Oxide (TMAO)

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