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Natural GLP-1 lasts only a minute or two before an enzyme inactivates it, so most of its signal stays near the gut

Alba-Roth J et al
Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Vigan P

Is the anaplerotic enzyme pyruvate carboxylase (PC) only expressed in astrocytes

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Lu Q, Yang L, Xiao JJ, Liu Q, Ni L, Hu JW, et al
