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The headline belongs at the top, not buried under the neurogenesis story: NSI-189's Phase 2 trial failed its primary endpoint for depression, and clinical development was discontinued

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These findings were supported by the relaxation of large vessels (ex vivo), mainly by acting on vascular endothelial cells but also on vascular smooth muscle cells, increasing NO production and migration of endothelial cells, activating the signal pathways of Src, Cav-1, and eNOS, and reducing proteinprotein interaction between eNOS and Cav-1 [121,122]

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