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Description
Although efforts were made to enhance transparency in the literature selection and to prioritize high-quality evidence, the absence of formal risk-of-bias assessment and quantitative synthesis should be considered when interpreting the conclusions
Mesotherapy offers a middle ground more targeted than topicals, less invasive than surgery, without hormonal side effects

Thats exactly what your tri-modality method is designed to do
Thats a discussion for a qualified dermatologist or aesthetic provider
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