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This condition results from a lack of intrinsic factor, a protein necessary for B12 absorption in the terminal ileum

345 The accumulation of proNGF and downregulation of TrkA (pro-survival signal) levels favor the predominance of pro-apoptotic signaling mediated by p75 NTR , further promoting the degeneration of basal forebrain cholinergic neurons

Vitamin B12 injections are a common and effective treatment for B12 deficiency

Enhanced investigation into NP toxicological profiles, coupled with innovations in targeted delivery systems to prolong circulatory residence time, could significantly improve treatment precision

Case reports, editorials, conference abstracts, and reviews were also excluded to maintain a focus on primary research

Kuang, J