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Not only does the resulting barrier disruption promote diarrhoea because of increased water concentration in the intestinal lumen, but there is also a greater opportunity for the development of secondary infections due to deeper tissue penetration by other pathogens and toxins (Guttman and Finlay 2009)

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Neutrophil extracellular traps (nets) take the central stage in driving autoimmune responses

doi:10.1006/bbrc.2000.3930

In addition, Na + also exerts atypical roles (Figure 3), which are not related to changes in driving forces nor directly change the cellular energy status

It is noteworthy that GPX3 loss was not associated with increased ROS levels or DNA damage, however exposure to carcinogens resulted in an increase in M2 macrophages, elevated proinflammatory mediators and increased DNA damage in tumor cells