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For ankle injuries specifically, subcutaneous injection near the affected area at 0.25 to 0.50 mg daily for 4 to 8 weeks represents the most common protocol among researchers and biohackers

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Cancer Discov 3:11901205 Chen Y, Terajima M, Yang Y, Sun L, Ahn Y-H, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM (2015) Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

Epub 2006 Sep 22

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Benoit YD, et al