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Allosteric coupling of drug binding and intracellular signaling in the A(2A) adenosine receptor

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de Almeida Chuffa LG, Carvalho RF, Justulin LA, et al

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5 Challenges and future research directions for DTP cells The mechanistic studies of DTP cells in hematological malignancies are still in an infant state, therefore targeting DTP cells to prevent or reduce drug resistance and disease relapse, remains both a challenge and an opportunity

This is FDA-approved and one of the clearest demonstrations that glutathione repletion has a life-saving clinical role