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FIGURE 7 5.2 Immunomodulation Immunomodulation is an innovative strategy recently introduced to improve the efficacy of currently unsuccessful regenerative approaches (Bloise et al., 2020)

2.3 Iron metabolism Iron is a trace element that exists in two forms in the human body: divalent iron (Fe 2+ , absorbable) and trivalent iron (Fe 3+ , non-absorbable) (68, 69)

Neutrophil infiltration and oxidant-production in human atherosclerotic carotid plaques

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This approach ensures that the nanomaterial will be activated primarily in the vicinity of pathogenic bacteria, which thrive in such environments and will remain inactive in the more neutral pH of healthy tissues, pH-responsive NPs are commonly made using materials like chitosan, which undergoes protonation in acidic conditions, leading to a release of encapsulated drugs or antimicrobial agents at infection sites