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Nuclear factor-erythroid 2-related factor 2 (Nrf2), a transcription factor that functions as a master regulator of cellular metabolism and anti-oxidant response [11], is also suppressed in patients with FA, in part due to FXN deficiency [12]
Improving Diabetes Care Clinic
(2022) 376:e066452

10.1038/s41586-023-06878-9 52 FuB.ShaoR.WangH.ChenG.BaiS.WangH

in turn, vitamin C can restore glutathione, allowing both to continue protecting cells