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The latter may indicate a heightened prevalence of smoking, obesity, and hyperglycemia, which can negatively impact cerebrovascular function

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In nsp13-2, residues N361 in the domain 1A, S468, T532 and D534 in the domain 2A and R178 and H230 in the domain 1B collectively contribute to template RNA recognition and elongation, demonstrating that nsp13-2 is directly involved in positioning downstream template RNA

References Association AP (2013) The diagnostic and statistical manual of mental disorders (DSM-5), 5th edn

Process Biochem 38:11331138 Wu G, Fang Y-Z, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health

One proposed function of sleep may be the mitigation of oxidative stress in both brain and peripheral tissues, contributing to the clearance of reactive species that accumulate during wakefulness