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The electrolyte imbalances likely arise as a result of damage to the lens cell membranes, especially those of the lens epithelial cells, which play the major role in maintaining the ionic and metabolic homeostasis of the entire lens

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In turn, necrotic or apoptotic hepatocytes emit massive amounts of DAMPs, which can be sensed by liver parenchymal and non-parenchymal cells (e.g., HSCs, LSECs, and KCs) via cognate pattern recognition receptors, thus amplifying inflammation and promoting cell death [9, 10]
