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Dihexa was administered to the APP/PS1 mice intraperitoneally from 6 to 9 months of age and 0.9% saline was administered to the wild type group once per day over a three month time period
Lipid ROS levels were measured through oxidation of the Bodipy 581/591 C11 (#D3861, Invitrogen) according to the manufacturers instructions

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Glutathione targets melanin at the production stage, helping to visibly improve the look of uneven tone and dullness over time
