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This pathway is engaged when CASP8 activity is inhibited downstream of death receptors, such as TNF receptor superfamily member 1A (TNFRSF1A)

doi: 10.1007/s10549-009-0594-8 11 HilvoMDenkertCLehtinenLMullerBBrockmollerSSeppanen-LaaksoTet al

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And somehow, it touches collagen production, wound healing, antioxidant activity, and the expression of thousands of genes at the same time

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Male mice underwent rapid loss of survival at extended time points, while female mice were largely unaffected