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Failure to perform cholecystectomy for acute cholecystitis in elderly patients is associated with increased morbidity, mortality, and cost

Histone modifications or modifying enzymes can regulate the expression levels of lncRNAs through direct or indirect interacting, consequently affecting the levels of associated miRNAs, and ultimately leading to the induction or repression for resistance-associated pathways

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Notably, the pharmacological inhibition of HDAC2 does not improve renal function or attenuate renal fibrosis