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(d) Loss of proteostasis involves autophagy and mitophagy, which control organized disposal of cellular debris and are linked to longevity (41)
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A large number of monoterpenoid indole and bisindole alkaloids have been identified in the genus Alstonia to date
Furthermore, the decline in GFR in advanced stages of CKD leads to the accumulation of drugs and chemical compounds that are typically metabolized or eliminated by the kidneys
