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10.1074/jbc.M702615200 48 MetzlerK

Its just mechanical wear and tear

Epigenetic plasticity is facilitated by enzymes that create and remove covalent modifications to DNA and histones (Domann et al., 2021[122])

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However, the enhanced neutrophil infiltration accompanied by blunted macrophage response after a severe overdose likely compromises hepatocyte regeneration, thus preventing liver recovery