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Thermal polarization favors the triplet (ortho) state, with 75% of H 2 molecules in this state at room temperature (ONeill et al., 2023)

2025;43:e70017

Autophagy enhancer-67 (AUTEN-67) and AUTEN-99, small-molecule inhibitors of MTMR, significantly increased autophagic flux in both in vitro and in vivo models

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In preclinical research, this combination formulation is being examined for coordinated effects on inflammation regulation, angiogenesis, fibroblast activity, and cellular stress responses