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The Antidepressant effects of an mGlu2/3 receptor antagonist and ketamine require AMPA receptor stimulation in the mPFC and subsequent activation of the 5-HT neurons in the DRN

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In contrast, the positive control group that received AZA showed significant liver and kidney injury, characterized by activation of Kupffer cells and localized hepatocellular necrosis with an influx of inflammatory cells and collagen fiber deposition around the central vein (Figures 11C, D), along with renal tubule epithelial vacuolar degeneration and interstitial edema (Figures 12C, D)

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emerging evidence also suggests that ferroptosis might serve a tumor suppressor function in removing cells that lack access to critical nutrients in their environment, or that have been compromised by infection or environmental stress, although these studies are still preliminary