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To probe the binding footprint, we quantified the frequency and character of base-specific interactions across all replicates, consistently revealing engagement with six base pairs from the minor groove (Supplementary Tables 59), which is in excellent agreement with our earlier FRET analysis with the F-DDH sequence

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doi: 10.1016/j.ccell.2022.08.012 139 AlharbiMLaiASharmaSKalita-de CroftPGodboleNCamposAet al