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In most cases of vitamin B12 hypersensitivity, various types of allergic reactions to parenterally administered cobalamins (intramuscular or subcutaneous) have been described [9,10,11,12,13,82,83,84,85]

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Normal immune activity in cancer patients gradually deteriorates as the thymus fails to replenish the peripheral T-cell pool after prolonged VEGF overexposure [33]