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is affiliated with the Medicine and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, TN, USA and is supported by the Krick-Brooks Chair in Nephrology, by NIH grants (R01-DK081646, R01-DK080821 and R01-DK101791), and by a Department of Veterans Affairs Merit Award (1I01BX002348)

Disclosure of interest: Marlies Wagner: nothing to disclose

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You will also find guidelines for using cold exposure safely and correctly

doi: 10.1016/j.psyneuen.2009.06.016

Monotherapy data suggests cagrilintide is effective at 2.4 mg weekly and retatrutide at 8-12 mg weekly, but these doses cannot simply be combined without understanding potential interactions