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The development and study of Melanotan II, including its structure-activity relationships, have led to insights into its mechanism of action and potential therapeutic applications, particularly in skin tanning and possibly treating certain skin conditions

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Finally, LDs can transfer oxidatively damaged proteins (including some unfolded proteins, BAK, BAX, etc.) from the endoplasmic reticulum and mitochondrial surface to themselves, thus inhibiting endoplasmic reticulum stress, as well as oxidative damage to the mitochondria, and reducing the occurrence of apoptosis [71]

Altogether, these results indicate that a switch to glycolytic metabolism alone is not sufficient to explain the hemocyte activation launched by the OXPHOS gene knockdown and subsequent decrease in mitochondrial membrane potential

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