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Mutations in LRRK2 impair its function and disrupt the formation of aggressive aggregates (aggresomes) that normally facilitate the autophagic clearance of protein aggregates (Stefanis et al., 2019)

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Biogerontology 21 (1), 109123

Most di-thiol Grx use monothiol mechanisms that take place in two steps: In the first step, the nucleophilic thiolate anion attacks the S -glutathionylated substrate protein, resulting in reduction of the mixed disulfide and the S -glutathionylated Grx (Grx-SSG) intermediate

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