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Research shows that after 6 weeks of elevated IGF-1, receptor density decreases by 40-60%, significantly blunting the peptide's effectiveness (Yakar et al., 2002)

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J Integr Plant Biol 50:216 Reichheld JP, Khafif M, Riondet C, Droux M, Bonnard G, Meyer Y (2007) Inactivation of thioredoxin reductases reveals a complex interplay between thioredoxin and glutathione pathways in Arabidopsis development