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Tolerance to the neuroplasticity effects has not been documented in research models, meaning repeated dosing continues to drive synaptic remodeling without requiring higher doses to achieve the same receptor activation

Paradoxically, despite receiving fewer days of antibiotics, the bacterial load-guided group had a longer time to next exacerbation compared with the patients who received a standard 14-day regimen [129]

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Radiographics (2006) 26(3):64157