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Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however

I also have a personal connection to the topic of hormone balance
This trial reported that the various treatments had no effect on attention compared to placebo, despite some improvements in nutrient status (105)

Further studies have shown that a restoration of B cell numbers correlated with the biological response to the TNF- inhibitor therapy [33,34]
Furthermore, Hayashi and collaborators showed that vitamin D supplementation in mouse model mitigated the clinical manifestations of influenza virus infection by suppressing virus replication and inflammation (Hayashi et al

10.1093/aje/kwv325 126
