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TMAO has also been found to promote plaque formation by stabilizing and adjusting the assembly of the amyloid- (A) peptide (Yang et al., 1999) and fibrillation of tau protein by inducing the secondary structure formation at the C terminus in vitro (Scaramozzino et al., 2006)

received honoraria from BMS, Gilead, Dong-A ST, Yuhan, Daewoong Beom Kyung Kim: Received honoraria from Samil, Dong-A ST, Yuhan, Celltrion, Deawoong, BMS, Chongkundang Byung Seok Kim: Received grants from Gilead, Abbvie, MSD, Dong-A ST, Daewoong, Ildong, Chongkundang

Frasca G, Cardile V, Puglia C, Bonina C, Bonina F

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L-Carnitine L-Tartarate supplement has antioxidant properties and is used to combat fatigue, muscle weakness and support weight loss

Current guidelines for acute coronary syndrome (ACS)/acute myocardial infarction (AMI) do not include L-carnitine, but as just reviewed in this systemic review, the evidence is far from weak and necessitates a larger multicenter trial to determine if indeed this simple, cost-effective, and safe agent will benefit patients suffering from acute myocardial function and perhaps also those with stable angina