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The remaining 50% is converted into TMA in the gut by the action of the enzyme, TMAO reductase.[12] Given the conflicting data, researchers have delved deeper into the L-Carnitine--TMAO connection and found that it is highly variable.[13] More specifically, the composition of an individuals gut microbiome can impact whether they are a low-TMAO producer or a high-TMAO producer. Researchers found that low TMAO producers demonstrated higher urine carnitine levels than high TMAO producers following 1,500mg of carnitine supplementation, thereby suggesting that the TMAO-producing status could influence carnitine bioavailability.[13] With this in mind, a new study crossed the science wire recently regarding the impact of carnitine supplementation on cardiovascular-related factors