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A recent study shows that IL-22 expression is significantly increased in the liver of female mice with APAP-induced hepatotoxicity, indicating the necessity to consider gender-dependent effects when using mice to establish a pathophysiological model of IL-22 [205]

1995 Dec 1;23(12):1976-83

(PubMed) Soares MJ, Satyanarayana K, Bamji MS, Jacob CM, Ramana YV, Rao SS

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Finally, B1 cells need to migrate to niches that support antibody production in order to increase secretion of IgM OSE