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Inhibition of PGC-1 expression has been shown to result in decreased expression of the mitochondrial fusion protein Mfn2, increased expression of p-Drp1, and increased mitochondrial fragmentation (Guo et al., 2015)

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(2011) 6:e26552

Detached cells were collected and centrifuged at 300 g for 5 min at room temperature

noticeable effects often after first use Clinical Insights: Effects may be more noticeable on days of higher cognitive demand Tolerated well at low doses with minimal side effects Can be used acutely or in cycles for sustained performance May be synergistic when paired with other mitochondrial therapies Investigated for neurodegenerative support (e.g., Alzheimers, Parkinsons) Methylene Blue helps supercharge your mitochondria and enhance brain function