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As such, differential diagnosis of FAOD remains important, to initially recognise symptoms and later to account for possible normal biochemical testing that may occur when blood samples are collected from patients not in catabolism [8]

This increase is even more pronounced with dietary supplements, whereas the effect of long-term consumption of TMAO precursors, reflecting dietary habits, is less clear

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A study of placebo responses on CRF confirmed that up to 29% of patients with advanced cancer experienced improved fatigue compared to usual care [82], indicating that the mechanism behind responses are complex