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Description
PMID 14752199.
Look out for signs like dark urine, dizziness, thirst, a dry mouth, or unusual fatigue, and seek medical advice if they occur
These may be due to defective DNA synthesis inhibiting replication in a site with a high turnover of cells
PARP1 uses NAD+ during DNA repair to blend poly(ADP-ribose) chains that bring repair proteins to damaged DNA sites
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Commonly, initial treatment may involve weekly injections for a few weeks, followed by monthly maintenance doses as needed
