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Second, while we identified core pathogenic pathways (tyrosine synthesis, TRP-mediated inflammation) and the BTK target, their specific molecular regulatory mechanisms in MS tumorigenesis and pain development remain to be elucidated by functional experiments

References Abdel-Wahab WM, Daifalla NS, Essawy AE (2023) L-methionine protects against nephrotoxicity induced by methotrexate through modulation of redox status and inflammation

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41 Alterations in cholinergic nerve activity associated with the expression of the GRM2 gene may cause an increase in pain threshold