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We could prove that this effect is linked to the presence of the Se core, since CS-NCs showed low levels of apoptosis in both cancerous and normal cells

The cell counting kit 8 (CCK-8) assay was used to investigate the therapeutic effect of preparation in two positive cells line (4T1 and MCF-7) and in a normal cell line (L929 cells)

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Once in the matrix, the ubiquinone moiety of MitoQ is reduced by complex II yielding ubiquinol, which acts as a potent antioxidant [71,72]

In contrast, endogenous 4-1BB signaling upregulates PGC-1 through stimulation of the p38-MAPK pathway, resulting in mitochondrial fusion and biogenesis and substantially increasing T cell respiratory capacity