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References Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE

Proc Natl Acad Sci USA 104:1336113366

So far, most of whats known about the substances effects on the brain comes from studies in rats and in cells grown in a lab dish not in people

A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder

Assessment and nutraceutical management of stress-induced adrenal dysfunction. Integrative Medicine 7.5 (2008): 18-25

What the authors report is that a 5 day treatment which almost abolished morphine analgesia in wild type mice produced no tolerance in knock-in animals [77]
