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[oai_citation:0PMC]( Key pointMost findings below come from in vitro or non-human in vivo experiments

Many experienced failed therapies and sought supportive care of symptomatology

Megson, Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage

The availability of therapeutic hydroxocobalamin to cells

Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: implications for liver transplantation