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Initially, in human trials, relatively low doses of the muscarinic receptor antagonist scopolamine were found to induce temporary cognitive defects

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Next, we examined whether the collagen crosslinking promoted by CAF sEVs could be blocked by interfering with the binding of sEVs to collagen

doi: 10.1016/j.cell.2018.08.049 111

Secondary end points included body-weight reductions of more than or equal to 20%, 25%, and 30%