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Maintaining aptitude and affinity under physiological settings is a significant problem, as variables like pH, salt content, and nucleases in biological fluids may damage aptamers or reduce their binding efficacy (Hu and Gao, 2025)

doi: 10.1073/pnas.1204023109

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Both IGF-1R and IR are preformed dimeric TK receptors made up by two extracellular -subunits and two -subunits involving a small extracellular domain, an intramembraneous one as well as an intracellular domain (Adams et al, 2000)

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