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NTDs include various malformations, such as lesions of the brain (e.g., anencephaly, encephalocele) or lesions of the spine (spina bifida), which are devastating and life-threatening (29)

Ten microlitres of the digested tissue medium was then mixed with 100 l of the DMMB dye

NICE guideline [NG130]

J.RamjeesinghM.et al (1992)
If the activity of methylmalonyl-CoA mutase is absent or decreased, e.g., due to hereditary defects of the apoprotein or to B 12 deficiency, toxic methylmalonic acid (MMA) is formed and the excess of methylmalonic acid is excreted in the urine
