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Among targeted agents, BCL-2 inhibitors-particularly venetoclax-have demonstrated the most pronounced therapeutic efficacy when combined with epigenetic modulators

Takada T, Nishida K, Doita M, Kurosaka M: Fas ligand exists on intervertebral disc cells: a potential molecular mechanism for immune privilege of the disc

Compagnone, N

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Altogether, pro-carcinogenic changes have a solid metabolic basis, and changes in metabolism are a leading therapeutic target for the treatment of patients with cancer, which is among the leading causes of mortality and, in many countries, risk factor number one ( 3.5 Infection and endotoxemia Most CNCDs involve endotoxemia, LGI, and/or intestinal permeability

Alshraim MO, Sangi S, Harisa GI, Alomrani AH, Yusuf O, Badran MM