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Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cellsimplications for blood-brain barrier physiology in Friedreichs ataxia

Cenizo et al (57) demonstrated that LOX expression levels in skin fibroblasts in adults were decreased compared with children, whereas, Langton et al (58) identified higher LOX activity in the elderly compared with young people

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The cellular and molecular changes triggered by ROS, as previously discussed, disrupt melanocyte homeostasis and contribute to pathological conditions 111

This neural pathway, known as the ligamento-muscular protective reflex, triggers a rapid contraction of the hamstring muscles, countering the anterior tibial translation and reducing the load on the ACL