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From a metabolic standpoint, directly inhibiting LDHA or employing glycolysis inhibitors can curtail lactate production at its source, thereby mitigating CIRI and aiding in the restoration of cellular function [113, 117]

The most prevalent cause of hypothyroidism is iodine deficiency, one of the crucial elements of thyroid hormones (51)

Funding The author(s) declare that no financial support was received for the research and/or publication of this article

Some, but not all, observational studies have found that elderly individuals with lower status of folate and/or vitamin B 12 may have poorer memory performance, especially episodic memory (i.e., memory of events, times, and places) (108-111)

Heusch G, Boengler K, Schulz R (2008) Cardioprotection: nitric oxide, protein kinases, and mitochondria